Myasthenia Gravis and Thymic Enlargement

Mona Mlika, Aida Ayadi-Kaddour, Imène Helal, Sadok Boudaya, Tarek Kilani, Faouzi Mezni


A causal relationship between the thymus gland and myasthenia gravis (MG) has been assumed for decades. However, this relationship is still a matter of conjecture and speculations and awaits definitive proof. Recently, myoid cells have been considered as effectors in the pathogenesis of MG as well as thymic enlargement (thymolipoma, true thymic hyperplasia).
Our objective is to discuss the role of myoid cells in the pathogenesis of MG associated with thymic enlargement.
we report a retrospective study about 6 cases of thymic enlargement with 4 cases of true thymic hyperplasia (TTH) and 2 cases of thymolipoma (TL).
The majority of our patients were men with a sex ratio of 4/2. Only 2 patients had a past medical history consistent for MG. Myoid cells were found in all cases.
Through our small study, the implication of myoid cells in the pathogenesis of the association MG-TL or TTH remains unproved.

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