Endometrial lymphoepithelioma-like carcinoma

Muath Rjoub, Nesreen Bataineh, Huda Zahawi, Najla Daoud


A case report of endometrial lymphoepithelioma-like carcinoma which is a rare carcinoma with fewer than 5 cases reported in the literature.
A 56 year old lady, presented with postmenopausal bleeding.
A total abdominal hysterectomy was performed, and gross examination revealed a previously opened distorted uterus measuring 16.5x10x6.5 cm. The endometrial cavity is filled with polypoid friable mass measuring 13.5x12x6 cm infiltrating the myometrium and extending grossly to the cervix. Light microscopic examination revealed markedly pleomorphic large tumor cells heavily infiltrated by lymphocytes extending to the cervical stroma. Immunohistochemical studies showed that the tumor cells are reactive for EMA, CAM 5.2 and vimentin. They are non-reactive for CK7, CK20, ER, WT1, Chromogranin, Synaptophysin, EBV, CD10, Actin, Desmin, CEA and HMWCK.
Lymphoepithelioma-like carcinoma is a rare carcinoma with few cases reported, characterized by pleomorphic cells and heavy lymphocytic infiltration. This case was not associated with Epstein-Barr virus infection as is the case with other reported cases in literature.

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