Aspirin Resistance in Patients Undergoing Coronary Artery Bypass Grafting

Bahi Hiyasat, Dina Sabha, Samhar Weshah, Amjad Bani Hani


Objective: Aspirin is a very common drug used after coronary artery bypass grafting. Significantly it is known to reduce mortality and the rate of ischemic complications after CABG. Resistance to Aspirin is a well known entity and has a great influence on clinical outcome. Our study will investigate the phenomenon of aspirin resistance in our patients that underwent coronary artery bypass surgery.

Methods: In a prospective controlled study 100 patients undergoing coronary artery bypass grafting (CABG) were included to investigate their sensitivity to Aspirin using platelets aggregometry study. Patients were followed up after one year to show their clinical outcome.

Results: 25 patients (25%) showed normal reaction to Aspirin (sensitive to treatment). 24 patients (24%) were preoperatively resistance to Aspirin and 51 patients (51%) developed this resistance postoperatively. The use of cardiopulmonary bypass, pump time and type of procedure showed no influence on the resistance rate. The one year follow up showed 5 deaths in the group of patients that developed the resistance preoperatively whereas resistance disappeared completely after one year in the perioperative resistant group.

Conclusions: Aspirin resistance occurs in a large portion of patients that undergo open heart surgery for coronary artery bypass grafting. It doesn’t appear to last permanently but rather for a brief period. The worse outcome for patients with Aspirin resistance could be assumpted by the increase mortality in this group.


Aspirin, CABG, Resistance

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