Chromosomal Changes in Childhood Acute Lymphoblastic Leukemia in Mosul

Muna A. Kashmoola, Sada J. Abdul-Ameer, Lika F. Gzeer

Abstract


Background and Objectives: To determine the most chromosomal abnormalities seen in Childhood Acute Lymphoblastic Leukemia (CALL) in Mosul, and to evaluate the correlations between clinical haematological and chromosomal abnormalities in CALL.

Pateints and Methods: Clinical notes, haematological parameters and cytogenetic analysis were studied for all patients. Cases were collected from oncology unit at Ibn Al-Atheer Teaching Hospital (ATH) in Mosul.

Results: The frequency of normal karyotype was (42.9%) while the frequency of pseudodiploidy, hyperdiploidy and hypodiploidy were (8.5%), (28.6%) and (20%), respectively. Cases with hyperdiploidy had significantly low Total Leukocyte Count (TLC), higher platelet count with (P<0.001), (P<0.05), respectively. Massive Hepato-Splenomegaly (MHS) was seen mainly in hypodiploidy group (P<0.01).

Conclusion: Normal karyotype was commonly seen in CALL in Mosul followed by hyperdiploidy. Good prognostic parameters were mainly seen in cases with hyperdiploidy

Keywords


Childhood Acute Lymphoblastic Leukaemia, Chromosomal Changes

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