Systemic Antifungal Agents

Walid Abuhammour, Eyassu Habte-Gabr


Fungal infections are being identified with an ever-increasing frequency in premature infants, immunocompromised children, patients receiving immunosuppressive agents, and in those with Acquired Immuno-Deficiency Syndrome (AIDS).1
Fungal infections traditionally have been classified into two distinctive classes: systemic and superficial. Consequently, antifungal agents are classified under two major headings, systemic and topical agents. In this review, only systemic antifungal agents will be discussed. There are only a few systemic antifungal drugs available for use and these are polyenes (Amphotericin B), pyrimidines (flucytosine) and azoles (ketoconazole, fluconazole and itraconazole), and Griseofulvin.

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