The Impact of Shift Work-Related Circadian Rhythm Disruption on Inflammatory Biomarkers

Maysa Suyagh, Eman Alefishat, Rana Abu Farha, Amal Akour, Violet Kasabri, Nailya Bulatova


OBJECTIVE: This study aimed to examine the effect of circadian rhythm disruption in night-shift workers on systemic
biomarkers of inflammation. METHODS Demographic data, clinical parameters and data on working patterns of 126
adult employees were documented. Serum levels of biomarkers were measured by enzymatic assay procedures.
RESULTS: Night-shift workers had markedly lower anti-inflammatory IL-10 and cardioprotective adiponectin and
MCP-1 compared to daytime workers. Night-shift workers’ MIF, LAR, TNF-α and TNF-α/IL-10 ratio were
significantly higher than those in day shift workers. Spearman's correlation showed that MIF, TNF-α, LAR and
TNF-α/IL-10 ratios were positively and significantly correlated with both the duration of the night shift and total
number of shifts (p < 0.05). Meanwhile, IL-10, adiponectin and MCP-1 were negatively and significantly
correlated with both variables (p < 0.05).
CONCLUSION: Night shift work may be closely associated with a higher propensity of cardiometabolic risk
factors clustering. Therefore, close monitoring of shift workers’ clinical status and lifestyle is warranted.


Night shift work, MIF, TNF-α/IL-10 ratio, IL-6, MCP-1, Leptin/Adiponectin ratio.

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