Solitary Median Maxillary Central Incisor: A Family Showing Dominant Inheritance and Mild Variable Expression

Yousif I. Omari, Ahmad S. Qadri, Oraib Y. Omari


We report on outbreed Jordanian family with three children, two girls and one boy, affected with Solitary Median Maxillary Central Incisor (SMMCI) and associated with minor midline anomalies. The two affected sisters had absence of frenulum. The boy had narrow high arch palate, depressed nasal bridge and broad nasal groove. The three children had no additional physical anomalies, were of normal learning abilities, and had a normal karyotype. The high recurrence of this SMMCI syndrome in one family together with the clinical findings and initial pedigree analysis suggest that SMMCI is a true pleiotropic and our patients may represent a previously undescribed autosomal dominant inheritance which leads to minor midline anomalies.


Solitary Central Incisor; Genetic Disease; Dental Disease; Family Study.

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