Human Parvovirus B 19 Antibody among Arthropathic Patients with Special Emphasis on Sickle Cell Diseases in Basrah

Daniah M. Shakir, Mubder A. Alkaissy, Hassan J. Hasony

Abstract


This is a case-controlled study conducted during the period from October 2006 till September 2007 in Basrah, with its aim being to estimate the overall prevalence of Human parvovirus B19 (HPV-B19) antibodies and their association to rheumatoid factor seropositivity among sickler/non-sickler arthropathic patients.

A total of 182 blood samples were collected from arthropathic patients attending the clinics of orthopaedic/rheumatology, clinic of internal medicine, Basrah General Hospital, Hemoglobinopathies Center at the Maternity and Children Hospital. The patients include 90 arthropathic patients with or without Sickle Cell Diseases (SCD) and 92 samples from control group. HPV-B19 IgG antibodies were serologically detected by an Enzyme-Linked Immuno-Sorbent Assay (ELISA) and rheumatoid factor was detected by Latex agglutination test.

The overall prevalence of HPV-B19 antibody in Basrah general population was 68.7%. The prevalence rate of antibodies among arthropathic patients in general was 76.9% but it was lower in arthropathic patients with SCD; 65.8%. These differences were statistically not significant (p>0.05) compared to control group. Eighty percent of individuals who had rheumatoid factor positive results were positive for HPV-B19 antibodies which indicate a significant association (P<0.05).

The seropositivity to HPV-B19 was increased with age. Small joints were the commonest site of manifestation which represents 78.1%, whether in a symmetrical (69.8%) or an asymmetrical pattern (74.5%).

HPV-B19 antibodies were significantly more (79.7%) among persons with history of blood transfusion compared to those with no such history (P<0.05). However, the types of SCD had no significant effect on the prevalence of HPV-B19 antibodies (P>0.05). There was a positive relation between HPV-B19 seropositivity and the duration of illness (p<0.05).

In conclusions, HPV-B19 is common with high prevalence in our region; there is a clear association between HPV-B19 infection and rheumatoid factor positivity. Individuals with sickle cell diseases, regardless of its type, and those with a history of blood transfusion were considered risk groups for acquiring HPV-B19 infections.

Keywords


Parvovirus B19, Arthropathic patients, Sickle Cell disease, Basrah.

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