Astroblastoma: A Case Report.

Fatima Obeidat, Fatin Al-Fares

Abstract


Astroblastoma is an uncommon neuroepithelial tumor of uncertain origin. Its original description as a separate glial tumor by Baily and Cushing was in 1924. It has been described in the literature in case reports and small series. It occurs predominantly in the cerebral hemisphere of young adults. It can be easily misdiagnosed as it is rarely encountered in clinical practice and share common radiological and histopathologic appearance with other glial neoplasms. On MR images, these tumors are cystic and solid lesions, with a characteristic bubbly appearance of the solid component. Histologically, astroblastoma is characterized by a typical perivascular pseudo-rosette pattern of GFAP-positive cells with broad, non-tapering processes radiating towards a central blood vessel.
We report a case of 20 year old female who presented in 1999 with tonic clonic generalized seizure. Brain MRI revealed a suprasellar mass, with obstruction of foramen of Monro and was diagnosed as a low grade glioma and received radiotherapy. In 2013 the patient complained of right temporal field visual loss, she underwent debulking operation and the mass showed characteristic histopathological features of astroblastoma.

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