The Effect of Toxoplasmosis on the Histology of a Mouse Small Intestine

Maysoon Al-Qzazz

Abstract


Background: This study is concerned with the effect of Toxoplasmosis on the histology of a mouse small intestine. A group of 10 mice were examined by a light microscope. The mice were inoculated intraperitoneally with placental fluid containing Toxoplasma gondii parasite to induce infection. After 10-15 days of inoculation, the small intestines of the mice were examined histologically by a light microscope.

Patient and Method: Isolation of the Toxoplasma gondii parasite came from pregnant women who suffered from acute Toxoplasmosis which was proven by an ElISA test showing the presence of the IgM antibody against the parasite in their blood. These women were chosen as a source of the Toxoplasma gondii parasite. Placental fluid was taken from those women after abortion and inoculated intraperitoneally in the mice.

Result: Histological examination of the mice’s small intestines showed the presence of Toxoplasma Gondii tachyzoites and bradyzoites invading all layers of the small intestine together with an intense inflammatory cellular infiltration, vasodilatation, congestion, hemorrhage and necrosis with the destruction of the villi, degeneration of the central lacteal inside the lamina propria of these villi. These changes indicated that the infection with the Toxoplasma Gondii parasite could affect all the organs in the body especially the small intestine.

Conclusion: Toxoplasma Gondii invade all the layers of the small intestine leading to the destruction and disturbance in their function.

Keywords


Toxoplasma gondii, mice intestines, Toxoplasmosis

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