Relationship of vitamin d deficiency to glycemic control in type 2 diabetes mellitus.

Nesreen Saadeh, Rami Saadeh, Ashraf Oweis, Saeed Alghamri

Abstract


Introduction: Vitamin D deficiency and diabetes mellitus are two widely prevalent conditions across all ages and races.
Observational studies show a consistent association between low vitamin D status, and prevalence of type 2 diabetes mellitus.
Our study aims to explore the prevalence of vitamin D deficiency among diabetics compared to non-diabetics in the population of northern Jordan, and the impact of vitamin D deficiency on glycemic control.
Methods: Glycosylated hemoglobin (HbA1c) and serum vitamin D were measured in a group of 140 type 2 diabetic patients and 129 non-diabetics.
Vitamin D was measured by radioimmunoassay and glycosylated hemoglobin (HbA1c) was measured by high performance liquid spectrophotometric chromatography.
Results: 25(OH) vitamin D levels were significantly lower in the diabetes mellitus type 2 patients than in the non-diabetic subjects (control group), being 12.45 ± 9.36 nmol/L vs 14.85±9.54 nmol/L respectively) (P-value 0.039). There was a significant difference in those with severe vitamin D deficiency (less than 20 nmol/L) between diabetics and non-diabetic subjects (control group) being 8.89±4.65 vs 10.69±4.68, (P-value = 0.001). Also, vitamin D deficient women had higher HbA1c levels.
Conclusion: Vitamin D deficiency is highly prevalent in our population and is more pronounced in patients with T2DM. Vitamin D deficiency’s association with higher HbA1c level, although statistically not significant, raises the possibility that vitamin D replacement may improve glycemic control.

Keywords


Vitamin D, Glycemic control, Diabetes, glycosylated hemoglobin

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