The Effect of COX1 and COX2 Inhibitors on the Antibacterial Activity of Selected Antibiotics against Standard and Methicillin- Resistant Staphylococcus aureus

Rula M. Darwish, T. Aburjai, S. Al-Khalil, K. Hadidi

Abstract


The antibacterial activity of combinations of COX1 or COX2 inhibitors and selected antibiotics, on methicillin resistance and standard strains of Staphylococcus aureus were assessed. Standardized serial dilution and viable counting methods were performed to evaluate the in vitro activity of seven different antibiotics and nine COX inhibitors. Common results between the two strains showed that the activity of gentamicin and chloramphenicol was improved by the use of COX1 and COX2 inhibitors, whereas nalidixic acid activity was not, when combined with both COX1 and COX2 inhibitors. The results showed that COX1 and COX2 inhibitors, except for celecoxib and rofecoxib, improved the activity of the antibiotics tested. Overall, the results suggest that COX inhibitors and antibiotics can be used advantageously together to improve the efficiency of antibioticsTaking into consideration the side effects of both drugs in the combinationfurther investigation might lead to use lower concentrations of antibiotics without compromising their effect, thus reducing the toxicity of these drugs.

Keywords


S. aureus, COX1 inhibitors, COX2 inhibitors, Antibiotic

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