Ternary Blends of Some Hydrophilic and Hydrophobic Polymers in Colon Targeted Delivery of Diethylcarbamazine

Clement Jackson, Martins Emeje, Sabinus Ofoefule

Abstract


Matrix tablets were prepared using blends of xanthan gum (XG), Guar gum (GG) and ethylcellulose (EC). The polymers were combined using six different ratios; 1:1:1, 1:2:1, 1:2:2, 2:2:1, 2:1:2 and 2:1:1 to produce formulations XG1GG1EC1, XG1GG2EC1, XG1GG2EC2, XG2GG2EC1. XG2GG1EC2 and XG2GG1EC1, respectively. Diethylcarbamazine (DEC) was used as the model drug. The ability of the prepared matrices to target drug release at the colon under the influence of colonic bacteria was evaluated using the dissolution medium containing 4% caecal content. Optimum release of drug was observed with formulations XG2GG2EC1 and XG2GG1EC1 with maximum drug release of 75 and 81%, respectively. Significant difference (P<0.05) was observed between drug release in dissolution medium with and without rat caecal contents for the batches of DEC tablets. Formulations (XG2GG2EC1 and XG2GG1EC1) followed Korsemeyer models (r2 = 0.9903 and r2 =0.9955) respectively via non – fickian diffusion (n ≥ 0.45).

Keywords


Matrix, guar, xanthan, ethylcellulose, Diethylcarbamazine, colon delivery

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