Epoxidationof Ferutinin by Different Fungi and Antibacterial Activity of its Metabolite

M. Iqbal Choudhary, Mohammad Yasin Mohammad, Syed Ghulam Musharraf, Atta ur-Rahman


Structural transformation of the sesquiterpene ester, ferutinin (1), by suspended fungal cultures of Aspergillus niger, Rhizopus stolonifer, and Fusarium lini, resulted in the formation of a metabolite. This metabolite was identified as ferutinin α-epoxide (2), by different spectroscopic techniques. Metabolite 2 showed a good antibacterial activity against Staphylococcus aureuscompared to ferutinin (1).


Sesquiterpene ester, ferutinin, fungal transformation, Aspergillus niger, Rhizopus stolonifer, Fusarium lini, ferutinin α-epoxide, epoxidation, Staphylococcus aureus, antibacterial activity.

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