Epoxidation of ferutinin by different fungi and antibacterial activity of its metabolite

Mohammad Yasin Mohammad


Structural transformation of the sesquiterpene ester, ferutinin (1), by suspended fungal cultures of Aspergillus niger, Rhizopus stolonifer, and Fusarium lini, resulted in the formation of a metabolite. This metabolite was identified as ferutinin α-epoxide (2), by different spectroscopic techniques. Metabolite 2 showed a good antibacterial activity against Staphylococcus aureus, comparable to ferutinin (1).


Sesquiterpene ester, ferutinin, fungal transformation, Aspergillus niger, Rhizopus stolonifer, Fusarium lini, ferutinin α-epoxide, epoxidation, Staphylococcus aureus, antibacterial activity.


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