Identification of the Consolidation Mechanisms of Emcompress ®

Adi I. Arida, Moawia M. Al-Tabakha, Basem F. Dababneh, Fuad H. Al-Jawad, Mai S. Khanfar

Abstract


This work is an attempt to elucidate the consolidation mechanisms of the powder Emcompress® under compression. Consolidation mechanisms play an important role in the forces of attraction between different particles, and this has extensively earned the interest of scientists due to the many newly and continuous findings in this area.
Emcompress® is a directly compressible excipient that undergoes extensive fragmentation under compression as demonstrated by large increase in its specific surface area under pressure, which is measured by gas adsorption technique, or other ones. Its different physical properties have been compared to that when adding povidone powder to it which is known to be used as a plastisizing material that decreases fragmentation of powder.
After the attempt to extract the pure forces which are responsible for the consolidation mechanisms of Emcompress®, many forces were involved in such consolidation. It was also noted that there is an indirectly proportional qualitative relationship between the specific surface area of Emcompress® and its average pore radius.
It has been shown that Emcompress® consolidates only by weak distance forces and mechanical interlocking.

Keywords


Consolidation mechanisms; Emcompress®; Gas adsorption; Specific surface area; Average pore radius; Wet granulation; Povidone

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