Oxytocin and cholecystokinin correlates with Metabolic syndrome's atherogenecity and adiposity indices

taiba Al-Athami1

Abstract


Abstract
OBJECTIVES our study aimed to investigate the correlation between plasma oxytocin (OXT) and cholecystokinin (CCK) as well as conicity index (CI), waist circumference (WC), waist circumference to hip circumference (WHR) ratio, red cell distribution width (RDW_CV%), mean platelet volume (MPV; fL) and TG\HDL-C ratio in metabolic syndrome (MetS) and Type-2 diabetes mellitus (T2DM) patients. METHODS In a cross-sectional design, 30 normoglycemic lean subjects (control), 30 nondiabetic MetS and 29 MetS-Pre/T2DM subjects were enrolled. Plasma OXT and CCK were measured by colorimetric-enzymatic assay and expressed as median (interquartile range). RESULTS CCK plasma levels (pmol\L) lacked pronounced discrepancy in MetS and MetS-pre/T2DM groups vs. lean –healthy controls (9.67 (7.14 – 13.7) and 6.73 (5.06 – 7.68) vs. 5.2 (2.86 – 7.56), respectively. OXT plasma concentrations (pg/mL) in both nondiabetic MetS and MetS-pre/T2DM groups were markedly (p<0.05) lower vs. controls’ (both 1975.4(1522.25-3191.15) and 1403(1033.95-2567.3) vs. 4176.6 (2407.13-5243.3) but no inter-MetS groups variations in OXT levels were detected. Besides the levels of following parameters and indices were substantially (p<0.05) elevated in both MetS and MetS-pre/T2DM groups when compared to normoglycemic-lean controls; (WC; cm) (102(93-110) and(100(96-107) vs.( 79(69-85)), WHR (0.91(0.88-0.93) and 0.9(0.87-0.92) vs. 0.82(0.75-0.91)), CI (1.15(1.08-1.22) and (1.15(1.06-1.18) vs. (0.97(0.87-1.05)), (RDW; CV%) (13.3(12.5-14) and 13.6(12.93-14.6) vs. 13.1(12.2-13.7)), TG\HDL-C ratio(5.105(3.79-6.75) and (4.68(2.16-6.55) vs. 1.31(0.94-1.97)), while (MPV;fL) was exceptionally higher for MetS-pre/T2DM group (but not for MetS group; p>0.05) when compared to control group (10.35(9.08-11.03), vs. 9.3(8.55-9.9)). CONCLUSIONS In nondiabetic MetS and MetS-pre\T2DM patients; OXT circulating concentrations (unlike CCK) were substantially decreased vs. lean controls.

Keywords


Cholecystokinin; Oxytocin; Conicity index; RDW and MPV; blood and adiposity indices.

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