Cardiac Energy Metabolism: A Potential Novel Therapeutic Target in the Treatment of Ischemic Heart Diseases

Osama Abo Alrob

Abstract


Despite decades of research, ischemic heart diseases (IHD) remain a major health problem in Jordan and
worldwide. Ischemia is associated with serious and deleterious perturbations in biochemical, and functional
characteristics of the heart. During ischemia, the heart increased it is reliance on glycolysis as an ultimate source
for ATP production. However, fatty acid β-oxidation rates significantly increased at reperfusion. The metabolic
dysregulation negatively impact both cardiac function and efficiency. Current treatment approaches of IHD mostly
focus on increasing oxygen supply (e.g. thrombolytic agents) or decreasing oxygen demand (e.g. beta-blockers).
However, therapeutic interventions aiming at improving cardiac efficiency of oxygen utilization have not gained
enough interest. In this review, this review focused on the metabolic pathways of fatty acid and glucose oxidation,
as well as the metabolic phenotype of the ischemic heart. Furthermore, this review will discuss the mechanisms of
metabolic modulators and how they can improve cardiac function in ischemia-reperfusion condition.

Keywords


MicroRNAs, Obesity, Diabetes, Fatty acid oxidation, MED13, Lipid metabolism.

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