Metal Complexes of Multidentate Schiff Base-Azo Ligand: Synthesis, Characterization and Biological Activity

Abbas Ali Salih Al-Hamdani


A series of transition metal complexes have been synthesized from the new Schiff base-azo ligand (H2L) derived from 4-(2-Amino-4-hydroxy-phenylazo)-1,5-dimethyl-2-phenyl-1,2-dihydro-pyrazol-5-one and o-phenylene diamine. The structural features have been confirmed from their elemental analyses, metal content, magnetic moment measurement, molar conductance, FT-IR, UV-Vis and NMR spectral studies. The data show that the complexes have the composition of [MH2L] type and octahedral geometry, with M=Zn(II), Cu(II), Ni(II) and Co(II).
Structural geometries of compounds were also suggested in gas phase by using theoretical treatments, using HyperChem-6 program for the molecular mechanics and semi-empirical calculations for ΔHƒ° and ΔEb at 298 K. Biological evaluations of considerable number of these compounds were done using organisms Escherichia coli and Staphylococcus aureus.


4-Aminoantipyrine, Schiff Base-Azo, Biological Activity, Structural Studies.

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